MilliporeSigma™ HAF/SART1, Mouse, Unlabeled, Clone: 1-2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC1149

Catalog No. MABC1149

Description

The human p53 tumor suppressor gene encodes a 393 amino acid phosphoprotein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins. p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions. The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage. This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1, and MDM2 genes. The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place. If repair is not successful, p53 initiates programmed cell death.

Specifications

• Antigen: HAF/SART1
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: O43290
• Immunogen: GST-tagged recombinant human HAF/SART1 C-terminal fragment.
• Quantity: 100 μL
• Research Discipline: Apoptosis & Cancer
• Gene ID (Entrez): NP_005137
• Target Species: Human
• Form: Purified

• Applications: Immunohistochemistry, Western Blot
• Clone: 1-2
• Conjugate: Unconjugated
• Gene: SART1
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 1-2 detected HAF shRNA-mediated HAF knockdown in MIA PaCa-2 human pancreatic carcinoma cells.
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.