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CD152 Hamster anti-Mouse, APC-R700, Clone: UC10-4F10-11, BD

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BDB565778 50 μg
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Catalog No. BDB565778 Supplier BD Biosciences Supplier No. 565778
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Description

Hamster Monoclonal Antibody

The UC10-4F10-11 monoclonal antibody specifically binds to CD152, which is also known as Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). CD152 is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor. CTLA-4 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. Whereas CD28 delivers a costimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses. CD152 may play roles in induction and/or maintenance of immunological tolerance, regulation of protective immunity, and autoimmune responses, and regulation of some aspects of thymocyte maturation. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leucocytes.

This antibody is conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD152
Applications Flow Cytometry
Classification Monoclonal
Clone UC10-4F10-11
Concentration 0.2mg/mL
Conjugate APC-R700
Description Ctla4; CTLA-4; Cytotoxic T-lymphocyte-associated protein 4; Ly-56
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Hamster
Immunogen Mouse CTLA-4 IgG2a Fusion
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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