ICOS (CD278) Armenian Hamster , PE, Clone: C398.4A, BD
Armenian Hamster Monoclonal Antibody
Supplier: BD Biosciences 565669
The C398.4A monoclonal antibody specifically binds to Inducible Costimulator (ICOS), which is also known as, CD278, Activation-inducible lymphocyte immunomediatory molecule (AILIM), or H4. ICOS is a type I transmembrane glycoprotein that forms a disulfide-linked homodimer and belongs to the CD28 family within the Ig superfamily. ICOS is expressed on either CD4+ or CD8+ single-positive mature thymocytes, T cells, or subsets of Innate Lymphoid Cells (ILC). Its expression is upregulated on activated T lymphocytes. ICOS is a costimulatory receptor that can bind to the B7-H2 ligand (CD275, ICOS-L) that is expressed on B cells, monocytes, macrophages, dendritic cells, and endothelial cells. ICOS plays a critical role in many types of T cell-dependent immunity. In the case of humoral immunity, for example, ICOS signaling is critical for the differentiation of T follicular helper (Tfh) cells and development of germinal centers. Although C398.4A was generated against mouse ICOS, this antibody reportedly crossreacts with human, rhesus, and rat ICOS.
|ICOS; AILIM; H4; Inducible T-cell costimulator; CVID1; Ly115|
|Human, Mouse, Rat, Rhesus Monkey|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Mouse D10.G4.1 T-cell clone|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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