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ICOS (CD278) Armenian Hamster , PE, Clone: C398.4A, BD

Armenian Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 565669

Catalog No. BDB565669



The C398.4A monoclonal antibody specifically binds to Inducible Costimulator (ICOS), which is also known as, CD278, Activation-inducible lymphocyte immunomediatory molecule (AILIM), or H4. ICOS is a type I transmembrane glycoprotein that forms a disulfide-linked homodimer and belongs to the CD28 family within the Ig superfamily. ICOS is expressed on either CD4+ or CD8+ single-positive mature thymocytes, T cells, or subsets of Innate Lymphoid Cells (ILC). Its expression is upregulated on activated T lymphocytes. ICOS is a costimulatory receptor that can bind to the B7-H2 ligand (CD275, ICOS-L) that is expressed on B cells, monocytes, macrophages, dendritic cells, and endothelial cells. ICOS plays a critical role in many types of T cell-dependent immunity. In the case of humoral immunity, for example, ICOS signaling is critical for the differentiation of T follicular helper (Tfh) cells and development of germinal centers. Although C398.4A was generated against mouse ICOS, this antibody reportedly crossreacts with human, rhesus, and rat ICOS.



ICOS (CD278)
Aqueous buffered solution containing ≤0.09% sodium azide.
Armenian Hamster
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
ICOS; AILIM; H4; Inducible T-cell costimulator; CVID1; Ly115
Affinity Purified
Mouse D10.G4.1 T-cell clone
Affinity Chromatography
Human, Murine, Rat, Rhesus
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