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CD183 Hamster anti-Mouse, Brilliant Violet 650, Clone: CXCR3-173, BD Optibuild™

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BDB740630 50 μg
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Catalog No. BDB740630 Supplier BD Biosciences Supplier No. 740630
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Description

Hamster Monoclonal Antibody

The CXCR3-173 monoclonal antibody specifically binds to mouse CD183, also known as CXCR3. CD183 is a seven transmembrane spanning, G protein-coupled chemokine receptor for CXC chemokines including CXCL9 (Mig), CXCL10 (IP-10) and CXCL11 (I-TAC). These chemokines are induced by inflammatory cytokines including IFN- γ, IFN- α / β , and TNF. CXCR3 is primarily expressed on activated/memory CD4+ and CD8+ T lymphocytes, Foxp+ regulatory T cells, natural killer T (NKT) cells and mature NK cells. Binding of chemokines to CXCR3 induces integrin activation, cytoskeletal changes, and chemotactic migration of activated lymphocytes. CD183 has been reported to play important roles in T cell recruitment and immune responses in a number of inflammatory and autoimmune diseases. The CXCR3-173 antibody reportedly inhibited in vitro chemotactic responses to CXCL10 or CXCL11 significantly but not to CXCL9. When administered systemically to mouse hosts, the CXCR3-173 antibody reportedly prolonged cardiac and pancreatic islet cell allograft survival. In the presence of CXCR3 ligands, especially, CXCL10 and CXCL11, staining with the antibody can be significantly blocked.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD183
Applications Flow Cytometry
Classification Monoclonal
Clone CXCR3-173
Concentration 0.2mg/mL
Conjugate Brilliant Violet 650
Description CXCR3; Cxcr3; CXC-R3; CXCR-3; GPR9; IP-10 Receptor
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Hamster
Immunogen Mouse CXCR3 peptide (amino acids 1-37)
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only

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