CD79b Hamster anti-Mouse, Brilliant Violet 421, Clone: HM79b (also known as HM79-16), BD Optibuild™
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 740056
The HM79b monoclonal antibody specifically recognizes an extracellular epitope of Ig β chain (Ig β or CD79b), a 35-40-kDa transmembrane protein which forms an 80-90-kDa disulfide-linked heterodimer with Ig α chain (Ig α or CD79a, 30-35 kDa). On mature B lymphocytes, the CD79a/CD79b heterodimers are non-covalently associated with surface IgM to form the B-cell receptor complex (BCR). The presence of CD79a/CD79b is necessary for surface expression of the BCR and signal transduction via the BCR in B lymphocytes and pre-B cells. It was recently reported that CD79b may be expressed on the cell surface preceding the appearance of surface IgM during B-lymphocyte development. At this pro-B-cell stage, CD79b participates in signal transduction involved in the regulation of B-cell development. It should be noted that multi-parameter flow cytometric analyses of bone marrow suspensions performed at BD Biosciences Pharmingen have been unable to detect surface staining by HM79b mAb on CD45R/B220+ IgM- cells.
|HM79b (also known as HM79-16)|
|Brilliant Violet 421|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Igβ; Igb; Ig-beta; Immunoglobulin-associated beta|
|Mouse B lymphoma, WEHI-123|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only