CD79b Hamster anti-Mouse, Brilliant Violet 650, Clone: HM79b (also known as HM79-16), BD Optibuild™
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 740537
The HM79b monoclonal antibody specifically recognizes an extracellular epitope of Ig β chain (Ig β or CD79b), a 35-40-kDa transmembrane protein which forms an 80-90-kDa disulfide-linked heterodimer with Ig α chain (Ig α or CD79a, 30-35 kDa). On mature B lymphocytes, the CD79a/CD79b heterodimers are non-covalently associated with surface IgM to form the B-cell receptor complex (BCR). The presence of CD79a/CD79b is necessary for surface expression of the BCR and signal transduction via the BCR in B lymphocytes and pre-B cells. It was recently reported that CD79b may be expressed on the cell surface preceding the appearance of surface IgM during B-lymphocyte development. At this pro-B-cell stage, CD79b participates in signal transduction involved in the regulation of B-cell development. It should be noted that multi-parameter flow cytometric analyses of bone marrow suspensions performed at BD Biosciences Pharmingen have been unable to detect surface staining by HM79b mAb on CD45R/B220+ IgM- cells.
|HM79b (also known as HM79-16)|
|Brilliant Violet 650|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Igβ; Igb; Ig-beta; Immunoglobulin-associated beta|
|Mouse B lymphoma, WEHI-123|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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