CD79b Hamster anti-Mouse, Brilliant Violet 786, Clone: HM79b (also known as HM79-16), BD Optibuild™

Hamster Monoclonal Antibody

Supplier:  BD Biosciences 740936

Catalog No. BDB740936

Description

The HM79b monoclonal antibody specifically recognizes an extracellular epitope of Ig β chain (Ig β or CD79b), a 35-40-kDa transmembrane protein which forms an 80-90-kDa disulfide-linked heterodimer with Ig α chain (Ig α or CD79a, 30-35 kDa). On mature B lymphocytes, the CD79a/CD79b heterodimers are non-covalently associated with surface IgM to form the B-cell receptor complex (BCR). The presence of CD79a/CD79b is necessary for surface expression of the BCR and signal transduction via the BCR in B lymphocytes and pre-B cells. It was recently reported that CD79b may be expressed on the cell surface preceding the appearance of surface IgM during B-lymphocyte development. At this pro-B-cell stage, CD79b participates in signal transduction involved in the regulation of B-cell development. It should be noted that multi-parameter flow cytometric analyses of bone marrow suspensions performed at BD Biosciences Pharmingen have been unable to detect surface staining by HM79b mAb on CD45R/B220+ IgM- cells.

Specifications

• Antigen: CD79b
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: Igβ; Igb; Ig-beta; Immunoglobulin-associated beta
• Host Species: Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2 λ1

• Applications: Flow Cytometry
• Clone: HM79b (also known as HM79-16)
• Conjugate: Brilliant Violet 786
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Mouse B lymphoma, WEHI-123
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only