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KLRG1 Hamster anti-Mouse, BUV395, Clone: 2F1, BD Optibuild™

Catalog No. BDB740279 Shop All BD Biosciences Products
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BDB740279 50 μg
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Catalog No. BDB740279 Supplier BD Biosciences Supplier No. 740279
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Description

Hamster Monoclonal Antibody

The 2F1 monoclonal antibody specifically binds to KLRG1 ( K iller cell L ectin-like R eceptor mmunoreceptor T yrosine-based I nhibitory M otif); its ligand has not been identified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Crosslinking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++ mobiliza tion and cytotoxic responses (but not IFN-γproduction) by CD8+ T cells and inhibits IFN-γand TNF production and redirected lysis by NK cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen KLRG1
Applications Flow Cytometry
Classification Monoclonal
Clone 2F1
Concentration 0.2mg/mL
Conjugate Brilliant Ultraviolet 395
Description Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA; 2F1 Ag
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Hamster
Immunogen A-LAK from C57BL/6 mice
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2 κ
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