Invitrogen™ HAP1 Monoclonal Antibody (1B6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA146412

Catalog No. MA146412

Description

In Western blot bands can be seen ~95 kDa for isoform A and ~110 kDa for isoform B. Suggested positive control: rat brain.

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

Specifications

• Antigen: HAP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% sodium azide
• Gene Accession No.: O35668, P54256, P54257
• Gene Symbols: HAP1
• Immunogen: Fusion protein from rat HAP1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 1B6
• Conjugate: Unconjugated
• Gene: HAP1
• Gene Alias: Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 15114, 29430, 9001
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid