Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. MA146412

Invitrogen™ HAP1 Monoclonal Antibody (1B6)
GREENER_CHOICE

Catalog No. MA146412
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
MA146412 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. MA146412 Supplier Invitrogen™ Supplier No. MA146412
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

In Western blot bands can be seen ~95 kDa for isoform A and ~110 kDa for isoform B. Suggested positive control: rat brain.

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAP1
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 1B6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% sodium azide
Gene HAP1
Gene Accession No. O35668, P54256, P54257
Gene Alias Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1
Gene Symbols HAP1
Host Species Mouse
Immunogen Fusion protein from rat HAP1.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15114, 29430, 9001
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.