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Invitrogen™ HAP1 Polyclonal Antibody
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Catalog No. PIPA5143859
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100 μg
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Catalog No. Quantity
PIPA5143859 100 μg
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Catalog No. PIPA5143859 Supplier Invitrogen™ Supplier No. PA5143859
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Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: rat liver tissue, mouse liver tissue, mouse Neuro-2a whole cell. ICC/IF: A549 cell. Flow: U937 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAP1
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene HAP1
Gene Accession No. O35668, P54256, P54257
Gene Alias Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1
Gene Symbols HAP1
Host Species Rabbit
Immunogen E.coli-derived human HAP1 recombinant protein (Position: M1-R671).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15114, 29430, 9001
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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