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Invitrogen™ HAP1 Polyclonal Antibody
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Catalog No. PIPA518616
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100 μg
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Catalog No. Quantity
PIPA518616 100 μg
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Catalog No. PIPA518616 Supplier Invitrogen™ Supplier No. PA518616
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Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAP1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene HAP1
Gene Accession No. P54257
Gene Alias Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1
Gene Symbols HAP1
Host Species Goat
Immunogen Synthetic peptide sequence (RYDFRYSEDREQ) corresponding to the internal amino acids of HAP1 (aa 521-533).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9001
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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