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Invitrogen™ HAP1 Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA5142270
This item is not returnable.
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Description
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
Specifications
HAP1 | |
Polyclonal | |
Unconjugated | |
HAP1 | |
Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1 | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
15114, 29430 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
O35668, P54256 | |
HAP1 | |
Peptide with sequence C-QDAHSKRQQKQK. | |
100 μg | |
Primary | |
Mouse, Rat | |
Antibody | |
IgG |
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