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HAP40/F8a Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981591
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100 μL
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50-198-1591 100 μL
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Catalog No. 50-198-1591 Supplier Bioss Supplier No. BS11696R
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Description

Rabbit Polyclonal Antibody

Huntington′s disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the Huntington protein. Huntington co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of Huntington but is actively targeted to the nucleus in the absence of Huntington. These observations suggest that HAP40 °Contributes to the function of normal Huntington and is a candidate for involvement in the aberrant nuclear localization of mutant Huntington found in degenerating neurons in Huntington′s disease.

Specifications

Antigen HAP40/F8a
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Alias AI852759; cpG island protein; DXUcsf1; F8a; F8a1; factor 8-associated gene A; Factor VIII associated protein; factor VIII intron 22 protein; RP23-114O19.4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human HAP40.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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