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Invitrogen™ HAPLN4 Monoclonal Antibody (1C1)
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Catalog No. PIMA523313
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100 μg
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Catalog No. Quantity
PIMA523313 100 μg
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Catalog No. PIMA523313 Supplier Invitrogen™ Supplier No. MA523313
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Description

Mouse Monoclonal Antibody

Peptide Sequence: QRGRKKVVHV LEGESGSVVV QTAPGQVVSH RGGTIVLPCR YHYEAAAHGH DGVRLKWTKV VDPLAFTDVF VALGPQHRAF GSYRGRAELQ GDGPGDASLV LRNVT.

Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAPLN4
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1C1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene HAPLN4
Gene Accession No. Q86UW8
Gene Alias 9330174O11; Brain link protein 2; brain linked protein 2; Bral2; Hapln4; Hyaluronan and proteoglycan link protein 4; hyaluronan and proteoglycan link protein 4; LOW QUALITY PROTEIN: hyaluronan and proteoglycan link protein 4; KIAA1926; link protein 4; LOW QUALITY PROTEIN: hyaluronan and proteoglycan link protein 4; Lpr4; si:dkey-19f23.2
Gene Symbols HAPLN4
Host Species Mouse
Immunogen HAPLN4 (NP_075378, 30 a.a. ~ 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 404037
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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