Invitrogen™ HAPLN4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA543425

Catalog No. PIPA543425

Description

Peptide sequence: NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 79%.

Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.

Specifications

• Antigen: HAPLN4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HAPLN4
• Gene Alias: 9330174O11; Brain link protein 2; brain linked protein 2; Bral2; Hapln4; Hyaluronan and proteoglycan link protein 4; hyaluronan and proteoglycan link protein 4; LOW QUALITY PROTEIN: hyaluronan and proteoglycan link protein 4; KIAA1926; link protein 4; LOW QUALITY PROTEIN: hyaluronan and proteoglycan link protein 4; Lpr4; si:dkey-19f23.2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 404037
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q86UW8
• Gene Symbols: HAPLN4
• Immunogen: Synthetic peptide directed towards the C-terminal of human HAPLN4 (aa 251-300).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov