Invitrogen™ HAPLN4 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547574

Catalog No. PIPA547574

Description

In Western blots, less than 1% cross-reactivity with recombinant human HAPLN1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.

Specifications

• Antigen: HAPLN4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HAPLN4
• Gene Alias: 9330174O11; Brain link protein 2; brain linked protein 2; Bral2; Hapln4; Hyaluronan and proteoglycan link protein 4; hyaluronan and proteoglycan link protein 4; LOW QUALITY PROTEIN: hyaluronan and proteoglycan link protein 4; KIAA1926; link protein 4; LOW QUALITY PROTEIN: hyaluronan and proteoglycan link protein 4; Lpr4; si:dkey-19f23.2
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 404037
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q86UW8
• Gene Symbols: HAPLN4
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human HAPLN4 Gln30-Val402.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG