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Invitrogen™ Haptoglobin beta Polyclonal Antibody
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Catalog No. PIPA5142825
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100 μg
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Catalog No. Quantity
PIPA5142825 100 μg
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Catalog No. PIPA5142825 Supplier Invitrogen™ Supplier No. PA5142825
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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognize both reported isoforms (NP_005134.1; NP_001119574.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [PMID: 21248165]. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. [PMID: 21248165].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Haptoglobin beta
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene HP
Gene Accession No. P00738, Q8SPS7
Gene Symbols HP
Host Species Goat
Immunogen Peptide with sequence C-STVPEKKTPKSP.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3240, 397061
Target Species Human, Pig
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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