Invitrogen™ HAS2 Monoclonal Antibody (2105CT879.18.75)

Catalog No.	Quantity
PIMA537783	200 μL

Catalog No. PIMA537783

Supplier: Invitrogen™ MA537783

Description

Mouse Monoclonal Antibody

HAS2 Monoclonal Antibody for Western Blot

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Specifications

• Antigen: HAS2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 2105CT879.18.75
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: HAS2
• Gene Accession No.: Q92819
• Gene Alias: HA synthase 2; Has2; Hyaluronan synthase 2; hyaluronan synthase homolog; Hyaluronan synthase type 2; hyaluronate synthase 2; Hyaluronic acid synthase 2
• Gene Symbols: HAS2
• Host Species: Mouse
• Immunogen: KLH conjugated synthetic peptide between 133-166 amino acids from the Central region of human HAS2.
• Purification Method: Protein G
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3037
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ