Invitrogen™ HAS2 Monoclonal Antibody (4E7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA517087

Catalog No. PIMA517087

Description

MA5-17087 targets HAS2 in indirect ELISA, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-17087 immunogen is purified recombinant fragment of human HAS2 (amino acids: 67-170) expressed in E. Coli. MA5-17087 detects HAS2 which has a predicted molecular weight of approximately 63.5kDa.

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Specifications

• Antigen: HAS2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q92819
• Gene Symbols: HAS2
• Immunogen: Purified recombinant fragment of human HAS2 (amino acids: 67-170) expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 4E7
• Conjugate: Unconjugated
• Gene: HAS2
• Gene Alias: HA synthase 2; Has2; Hyaluronan synthase 2; hyaluronan synthase homolog; Hyaluronan synthase type 2; hyaluronate synthase 2; Hyaluronic acid synthase 2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 3037
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid