HAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 156091AP
DescriptionHAS1, HAS2 and HAS3 are HA (hyaluro or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluro and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluro synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGFbeta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|HA synthase 3, HAS3, hyaluro synthase 3, Hyaluronate synthase 3, Hyaluronic acid synthase 3|
|15118, 266805, 3038|
|Immunohistochemistry (Paraffin), Western Blot|
|HAS3 Fusion Protein Ag7999|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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