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HAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 156091AP

Catalog No. 50-173-0348


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Description

Description

HAS1, HAS2 and HAS3 are HA (hyaluro or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluro and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluro synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGFbeta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1.
Specifications

Specifications

HAS3
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O00219, O08650
HA synthase 3, HAS3, hyaluro synthase 3, Hyaluronate synthase 3, Hyaluronic acid synthase 3
Rabbit
IgG
150 μL
-20°C
Primary
15118, 266805, 3038
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
HAS3
Liquid
Has3
HAS3 Fusion Protein Ag7999
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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