Invitrogen™ HAT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596526

Catalog No. PIPA596526

Description

Immunogen sequence: TPFQGQGHGA QLLETVHRYY TEFPTVLDIT AEDPSKSYVK LRDFVLVKLC QDLPCFSREK LMQGFNEDMA IEAQQKFKIN KQHARRVYEI LRLLVTDMSD AEQYRSYRLD IKRRLISPYK KKQRDLAKMR KCLRPEELTN QMNQIEISMQ HEQLEESFQE LVEDYRRVIE RLAQE; Positive Samples: MCF7, SW480, Jurkat, 293T, HeLa, HepG2, U-251MG, Mouse spleen, Rat testis; Cellular Location: Cytoplasm, Nucleus, Nucleus matrix, nucleoplasm.

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.

Specifications

• Antigen: HAT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HAT1
• Gene Alias: 2410071B14Rik; AA536933; HAT1; Hat-1; histidine aminotransferase 1; histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit; histone aminotransferase 1; KAT1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107435, 296501, 8520
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.38 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O14929, Q5M939, Q8BY71
• Gene Symbols: HAT1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 245-419 of human KAT1/KAT1/HAT1 (NP_0036331).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG