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HAVCR2 Mouse anti-Human, Clone: OTI4E4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF813028

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.Specifications
HAVCR2 | |
Monoclonal | |
Unconjugated | |
HAVCR2 | |
CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3 | |
Mouse | |
Affinity Chromatography | |
RUO | |
84868 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Flow Cytometry, Western Blot | |
OTI4E4 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q8TDQ0 | |
HAVCR2 | |
Full length human recombit protein of human HAVCR2 produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2a |
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