HAVCR2 Mouse anti-Human, Clone: OTI7B10, lyophilized, TrueMAB™

Catalog No.	Quantity
50-167-0943	100 μg

Catalog No. 50-167-0943 Supplier OriGene Supplier No. CF812575

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.

Specifications

• Antigen: HAVCR2
• Applications: Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: OTI7B10
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: HAVCR2
• Gene Accession No.: Q8TDQ0
• Gene Alias: CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
• Gene Symbols: HAVCR2
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human HAVCR2 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 84868
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1