Invitrogen™ HCAR2/HCAR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599937

Catalog No. PIPA599937

Description

Antibody detects endogenous levels of total GPR109A/B.

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Specifications

• Antigen: HCAR2/HCAR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HCAR3
• Gene Alias: G protein-coupled receptor 109A; G protein-coupled receptor 109B; G protein-coupled receptor HM74a; GPR109A; GPR109B; G-protein coupled receptor 109A; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74A; G-protein coupled receptor HM74B; GTP-binding protein; HCA2; HCA3; HCAR2; HCAR3; HM74; HM74a; HM74B; hydroxycarboxylic acid receptor 2; hydroxy-carboxylic acid receptor 2; Hydroxycarboxylic acid receptor 3; hydroxy-carboxylic acid receptor 3; niacin receptor 1; Niacin receptor 2; NIACR1; NIACR2; Nicotinic acid receptor; nicotinic acid receptor 2; PUMAG; Puma-g; putative chemokine receptor
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 338442, 8843
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P49019, Q8TDS4
• Gene Symbols: HCAR2, HCAR3
• Immunogen: A synthesized peptide derived from human HCAR2(Accession Q8TDS4), corresponding to amino acid residues F304-S354.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov