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Invitrogen™ HCN2 Monoclonal Antibody (S71)
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Catalog No. PIMA527718
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100 μg
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Catalog No. Quantity
PIMA527718 100 μg
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Catalog No. PIMA527718 Supplier Invitrogen™ Supplier No. MA527718
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-27718 was sufficient for detection of HCN2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 95kDa. No cross-reactivity against HCN1.

Hyperpolarization-activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HCN2
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
Classification Monoclonal
Clone S71
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene HCN2
Gene Accession No. O88703, Q9JKA9
Gene Alias BCNG2; BCNG-2; brain cyclic nucleotide gated channel 2; brain cyclic nucleotide-gated channel 2; Hac1; HAC-1; HCN2; hyperpolarization activated cyclic nucleotide gated potassium channel 2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; hyperpolarization-activated cation channel 1; hyperpolarization-activated, cyclic nucleotide-gated K+ 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; trls
Gene Symbols HCN2
Host Species Mouse
Immunogen Fusion protein amino acids 761-863 of rat HCN2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114244, 15166
Target Species Mouse, Rat, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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