Invitrogen™ HDAC3 Monoclonal Antibody (3G6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA518069

Catalog No. PIMA518069

Description

Western blot detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Specifications

• Antigen: HDAC3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O15379, O88895
• Gene Symbols: HDAC3
• Immunogen: Human C-terminal peptide (identical in mouse). Sequence: aa 411-428 (NEFYDGDHDNDKESDVEI).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 3G6
• Conjugate: Unconjugated
• Gene: HDAC3
• Gene Alias: AW537363; HD3; Hdac3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; histone deacetylase 3; histone deacetylase 3-like protein; RPD3; RPD3-2; SMAP45
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 15183, 8841
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid