Invitrogen™ HDAC3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120454

Catalog No. PIPA5120454

Description

Positive test controls include: HeLa, K-562, NIH/3T3, Mouse brain, Mouse spleen, Rat kidney. The target is usually found in the following locations: Cytoplasm, Nucleus, cytosol. Immunogen sequence: FEYFAPDFTL HPDVSTRIEN QNSRQYLDQI RQTIFENLKM LNHAPSVQIH DVPADLLTYD RTDEADAEER GPEENYSRPE APNEFYDGDH DNDKESDVEI.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Specifications

• Antigen: HDAC3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HDAC3
• Gene Alias: AW537363; HD3; Hdac3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; histone deacetylase 3; histone deacetylase 3-like protein; RPD3; RPD3-2; SMAP45
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15183, 84578, 8841
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.24 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O15379, O88895, Q6P6W3
• Gene Symbols: HDAC3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 329-428 of human HDAC3 (NP_0038742).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG