Invitrogen™ HDAC4 Monoclonal Antibody (7B2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515580

Catalog No. PIMA515580

Description

MA5-15580 targets HDAC4 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15580 immunogen is purified recombinant fragment of human HDAC4 expressed in E. Coli. MA5-15580 detects HDAC4 which has a predicted molecular weight of approximately 119 kDa.

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

Specifications

• Antigen: HDAC4
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: P56524, Q6NZM9
• Gene Symbols: HDAC4
• Immunogen: Purified recombinant fragment of human HDAC4 expressed in E. Coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: ChIP Assay, ELISA, Western Blot
• Clone: 7B2
• Conjugate: Unconjugated
• Gene: HDAC4
• Gene Alias: 4932408F19Rik; AHO3; AI047285; BDMR; DKFZp779K1053; HA6116; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC-4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDAC-A; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0288; KIAA0744; MITR
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 208727, 9759
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov