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Invitrogen™ HDAC4 Monoclonal Antibody (7B2)
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Catalog No. PIMA515580
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100 μL
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PIMA515580 100 μL
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Catalog No. PIMA515580 Supplier Invitrogen™ Supplier No. MA515580
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Description

Mouse Monoclonal Antibody

MA5-15580 targets HDAC4 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15580 immunogen is purified recombinant fragment of human HDAC4 expressed in E. Coli. MA5-15580 detects HDAC4 which has a predicted molecular weight of approximately 119 kDa.

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).
TRUSTED_SUSTAINABILITY

Specifications

Antigen HDAC4
Applications ChIP Assay, ELISA, Western Blot
Classification Monoclonal
Clone 7B2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene HDAC4
Gene Accession No. P56524, Q6NZM9
Gene Alias 4932408F19Rik; AHO3; AI047285; BDMR; DKFZp779K1053; HA6116; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC-4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDAC-A; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0288; KIAA0744; MITR
Gene Symbols HDAC4
Host Species Mouse
Immunogen Purified recombinant fragment of human HDAC4 expressed in E. Coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 208727, 9759
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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