HDAC4 Monoclonal Antibody (OTI1E12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA805008

Catalog No. 50-168-0516

Description

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

Specifications

• Antigen: HDAC4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P56524
• Gene Symbols: HDAC4
• Immunogen: Full length human recombit protein of human HDAC4 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1E12
• Conjugate: Unconjugated
• Gene: HDAC4
• Gene Alias: AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9759
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid