HDAC4 Mouse anti-Human, Clone: OTI4A4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805010

Catalog No. 50-166-7248

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

Specifications

• Antigen: HDAC4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: HDAC4
• Gene Alias: AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9759
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI4A4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P56524
• Gene Symbols: HDAC4
• Immunogen: Full length human recombit protein of human HDAC4 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1