HDAC7 Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-157-1821	100 μL
50-157-1822	10 μL

Catalog No. 50-157-1821 Supplier Bethyl Laboratories, Inc Supplier No. IHC00283

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Guinea pig_10141, Orangutan, Monkey, Gorilla, Chimpanzee and Northern

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individualsubstrate specificity and function in vivo.

Specifications

• Antigen: HDAC7
• Applications: Immunohistochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: HDAC7
• Gene Accession No.: Q8C2B3, Q8WUI4
• Gene Alias: Histone deacetylase 7
• Gene Symbols: Hdac7
• Host Species: Rabbit
• Immunogen: Between 902 and 952
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51564, 56233
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG