Invitrogen™ HDAC8 Recombinant Rabbit Monoclonal Antibody (1O2Y5)

Catalog No.	Quantity
PIMA535729	100 μL

Catalog No. PIMA535729 Supplier Invitrogen™ Supplier No. MA535729

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Specifications

• Antigen: HDAC8
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 1O2Y5
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
• Gene: HDAC8
• Gene Accession No.: B1WC68, Q8VH37, Q9BY41
• Gene Alias: 2610007D20Rik; CDA07; CDLS5; HD8; Hdac8; HDACL1; histone deacetylase 8; histone deacetylase-like 1; MRXS6; RGD1562895; RPD3; WTS
• Gene Symbols: HDAC8
• Host Species: Rabbit
• Immunogen: Synthetic peptide.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 363481, 55869, 70315
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG