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HDAC8 Monoclonal Antibody (HDAC8-48), Invitrogen™

Catalog No. PIMA125458
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50 μL
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Catalog No. Quantity
PIMA125458 50 μL
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Catalog No. PIMA125458 Supplier Thermo Scientific Supplier No. MA125458

Description

Mouse Monoclonal Antibody

Recommended positive controls: HeLa nuclear extract. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HDAC8
Applications ELISA, Western Blot
Classification Monoclonal
Clone HDAC8-48
Concentration 2.4 mg/mL
Conjugate Unconjugated
Formulation 0.01M PBS with 15mM sodium azide; pH 7.4
Gene HDAC8
Gene Accession No. Q9BY41
Gene Alias 2610007D20Rik; CDA07; CDLS5; HD8; Hdac8; HDACL1; histone deacetylase 8; histone deacetylase-like 1; MRXS6; RGD1562895; RPD3; WTS
Gene Symbols HDAC8
Host Species Mouse
Immunogen Recombinant, full length human protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55869
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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