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Invitrogen™ HDAC8 Polyclonal Antibody
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Catalog No. PIPA583916
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100 μL
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PIPA583916 100 μL
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Catalog No. PIPA583916 Supplier Invitrogen™ Supplier No. PA583916
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VLKEVYQAFN PKAVVLQLGA DTIAGDPMCS FNMTPVGIGK CLKYILQWQL ATLILGGGGY NLANTARCWT YLTGVILGKT LSSEIPDHEF Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HDAC8
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HDAC8
Gene Accession No. Q9BY41
Gene Alias 2610007D20Rik; CDA07; CDLS5; HD8; Hdac8; HDACL1; histone deacetylase 8; histone deacetylase-like 1; MRXS6; RGD1562895; RPD3; WTS
Gene Symbols HDAC8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human HDAC8. Recombinant protein control fragment (Product #RP-92211).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55869
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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