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HDAC9 Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501994119
Encompass
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50-199-4119 10 μL
50-199-4118 100 μL
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Catalog No. 50-199-4119 Supplier Active Motif Supplier No. 39794
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Description

Rabbit Polyclonal Antibody

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.

Specifications

Antigen HDAC9
Applications Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Hdac9
Gene Accession No. Q9UKV0
Gene Alias AV022454; D030072B18Rik; DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC7; Hdac7b; HDAC9; HDAC9B; HDAC9FL; Hdrp; histone deacetylase 4/5-related protein; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; Mitr; mKIAA0744; RGD1310748; RGD1563092; TWIST
Gene Symbols Hdac9
Host Species Rabbit
Immunogen This HDAC9 antibody was raised against a peptide derived from the C-terminus of human HDAC9.
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9734
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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