Invitrogen™ HEC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596314

Catalog No. PIPA596314

Description

Immunogen sequence: ETIKQENTRL QNIIDNQKYS VADIERINHE RNELQQTINK LTKDLEAEQQ KLWNEELKYA RGKEAIETQL AEYHKLARKL KLIPKGAENS KGYDFEIKFN PEAGANCLVK YRAQVYVPLK ELLNETEEEI NKALNKKMGL EDTLEQLNAM ITESKRSVRT LKEEVQKLDD LYQQKIKEAE EEDEKCASEL ESLEKHKHLL ESTVNQGLSE AMNELDAVQR EYQLVVQTTT EERRKVGNNL QRLLEMVATH VGSVEKHLEE QIAKVDREYE ECMSEDLSEN IKEIRDKYEK KATLIKSSEE; Positive Samples: K-562, Lovo, MCF7, 22Rv1, THP-1, 293T, Mouse testis; Cellular Location: Chromosome, Nucleus, centromere, kinetochore.

Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.

Specifications

• Antigen: HEC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NDC80
• Gene Alias: 2610020P18Rik; AV139730; HEC; HEC1; HEC-1; HEC2; HEC4; Highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; Kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80; NDC80 homolog, kinetochore complex component; NDC80 homolog, kinetochore complex component (S. cerevisiae); NDC80 kinetochore complex component; NDC80 kinetochore complex component homolog; NDC80, kinetochore complex component; putative kinetochore protein NDC80 like protein; retinoblastoma-associated protein HEC; TID3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10403, 67052
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.49 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O14777, Q9D0F1
• Gene Symbols: NDC80
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 343-642 of human HEC1/HEC1/NDC80 (NP_0060921).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov