Invitrogen™ HECW1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115349

Catalog No. PIPA5115349

Description

Antibody detects endogenous levels of total HECW1.

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Specifications

• Antigen: HECW1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HECW1
• Gene Alias: E3 ubiquitin-protein ligase HECW1; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; HECW1; hNEDL1; KIAA0322; NEDD4-like E3 ubiquitin-protein ligase 1; NEDD4-like ubiquitin-protein ligase 1; NEDL1; RGD1561038
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23072, 291209
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q76N89
• Gene Symbols: HECW1
• Immunogen: A synthesized peptide derived from human HECW1(Accession Q76N89), corresponding to amino acid residues S589-S639.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov