Invitrogen™ HECW1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552457

Catalog No. PIPA552457

Description

Immunogen sequence: STEPESAQIQ DSPMNNLMES GSGEPRSEAP ESSESWKPEQ LGEGSVPDGP GNQSIELSRP AEEAAVITEA GDQGMVSVGP EGAGELLAQV QKDIQPAPSA EELAEQLDLG EEASALLLED GEAPAS Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 44%.

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Specifications

• Antigen: HECW1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HECW1
• Gene Alias: E3 ubiquitin-protein ligase HECW1; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; HECW1; hNEDL1; KIAA0322; NEDD4-like E3 ubiquitin-protein ligase 1; NEDD4-like ubiquitin-protein ligase 1; NEDL1; RGD1561038
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23072
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q76N89
• Gene Symbols: HECW1
• Immunogen: Recombinant protein corresponding to Human HECW1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG