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  7. Precipio™ HemeScreen MPN Panels

Precipio™ HemeScreen MPN Panels

Catalog No. 22021968
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4 Samples
8 Samples
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Catalog No. Quantity
22-021-968 4 Samples
22-021-969 8 Samples
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Catalog No. 22-021-968 Supplier Precipio™ Supplier No. HS4PMPN
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Description

The HemeScreen MPN Panel-4 is an RUO pre-plated kit used to detect MPN-related gene mutations for JAK2, MPL, and CALR genes through HRM methods.

HemeScreen is a proprietary set of RUO (Research Use Only) reagents used to screen the wild type (Negative) from Mutated (Positive) genes in a simplified workflow relative to alternative molecular testing technologies (RT-PCR or NGS).

  • Pre-plated configuration with embedded mutant, wild type, and NTC controls to run 4 or 8 samples in duplicate
  • Simplified workflow and reduced chance of error
  • Data capture during thermocycling
  • Fast turnaround time
  • Broad mutation detection (SNPs, Modifications, Indels)
  • Low limits of detection
  • Results are qualitative and DNA sequencing is required to identify specific isoforms
  • LOD: 5%
  • Assay includes Primers-Mastermix Mix and controls
  • Requires HRM-enabled RT-PCR (example Thermo Fisher™ Quantstudio 3 or higher)

Specifications

Content And Storage 96-well Plate with Gene Targets, Positive, Negative, and Wild Type Controls. Store at -20°C
Detection Method HRM
Format Kit, 96-well Plate
PCR Method qPCR
Technique PCR, HRM Analysis
For Use With (Equipment) PCR Instruments
Gene Symbol CALR,JAK2,MPL
Genotyping Target SNPs, Indels, Modifications
Includes Label or Dye Yes
Kit Type HRM DNA Mutation Detection Kit
Label or Dye High Resolution Melting (HRM)
No. of Tests 4 Test
Primer PCR Primers
Product Line HemeScreen
Product Type Genotyping Kit (HRM)
Quantity 4 Samples
Research Category Cancer
Sensitivity 0.95
Shipping Condition Dry Ice
Sufficient For 4 Samples
Target JAK2 Ex. 14 (V617F), JAK2 Ex. 12, JAK2 Ex. 13, MPL, CALR
Target Loci JAK2 (Exon 12, Exon 13, Exon 14), MPL, CALR
Target Organism Class Human
Target Specificity >99%
For Use With (Application) Real Time PCR (qPCR)
Compatibility HRM-enabled RT-PCR Instruments
Reaction Format Master Mix
Reagent Type PCR Reagent, HRM Assay Reagent
Sample Type DNA (whole blood or bone marrow)
Starting Material DNA
Volume 20 μL
Includes 96-well plate with gene targets, Primers and MasterMix mix, Positive controls, Negative controls, Wild-Type controls, No Template control (NTC)
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