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Invitrogen™ HENMT1 Polyclonal Antibody
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Catalog No. PIPA528543
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100 μL
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PIPA528543 100 μL
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Catalog No. PIPA528543 Supplier Invitrogen™ Supplier No. PA528543
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji. Predicted reactivity: Rhesus Monkey (99%), Chimpanzee (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

HENMT1 (HEN Methyltransferase 1) is a small RNA methyltransferase gene crucial for the stability and functionality of PIWI-interacting RNAs (piRNAs). It is located in human chromosome 1 at the p36.31 locus. The HENMT1 protein catalyzes the 2'-O-methylation at the 3' end of piRNAs in a Mg2+ dependent manner. This modification is essential for piRNA maturation and stability, ensuring the repression of transposable elements (TEs) during spermatogenesis and maintaining genomic integrity in male germ cells. Studies have highlighted the impact of HENMT1 mutations causing male infertility due to disrupted piRNA pathway and improper germ cell gene regulation. The enzymatic activity of HENMT1 is not only significant for male fertility but is also involved in maintaining piRNA stability in female germ cells, although females with HENMT1 mutations show subfertility.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HENMT1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene HENMT1
Gene Accession No. Q5T8I9
Gene Alias 4921515J06Rik; C1orf59; HEN1; HEN1 methyltransferase homolog 1; HEN1 methyltransferase homolog 1 (Arabidopsis); Henmt1; hua enhancer 1 homolog 1; mHEN1; RGD1306230; Small RNA 2'-O-methyltransferase
Gene Symbols HENMT1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human HENMT1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 113802
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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