Invitrogen™ Hepatitis B Virus preS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14105

Catalog No. PA14105

Description

PA1-4105 detects the Hepatitis B Virus. PA1-4105 has been successfully used in Western blot procedures. The PA1-4105 immunogen is a synthetic peptide corresponding to residues C(132) Q D P R V R G L Y F P A G G(145) of preS2 HBV.

The hepatitis B virus is an important cause of acute and chronic liver disease. It is also the most common form of parenterally transmitted viral hepatitis. The HBV surface protein antigens (HBsAg) are comprised of three carboxyl co terminal HBs proteins termed large (LHBs), middle (MHBs) and small (SHBs, also called major) protein. LHBs and MHBs also share the highly hydrophobic, repetitive, membrane spanning S domain. In addition, MHBs has a 55 amino acid region called preS2. The virus is estimated to affect some 350 million people worldwide. Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries. Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus. In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas. There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.

Specifications

• Antigen: Hepatitis B Virus preS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: HBV; HBVgp4; hepatitis b virus pre-s receptor fragment; HepB; pre-s2
• Immunogen: Synthetic peptide corresponding to residues C(132) Q D P R V R G L Y F P A G G(145) of preS2 HBV.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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