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Invitrogen™ Hepsin Monoclonal Antibody (506220)
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Catalog No. PIMA524218
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100 μg
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Catalog No. Quantity
PIMA524218 100 μg
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Catalog No. PIMA524218 Supplier Invitrogen™ Supplier No. MA524218
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Description

Mouse Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

Hepsin, encoded by the HPN gene, is a type II transmembrane serine protease prominently expressed in tissues such as the liver, kidney, and prostate. Hepsin plays a crucial role in proteolytic processes involved in extracellular matrix remodeling, cell growth, and development. It is known for activating precursor molecules, including hepatocyte growth factor (HGF), which is essential for liver development and regeneration. Furthermore, hepsin's involvement extends to influencing cell signaling pathways related to tissue homeostasis and repair. In the context of cancer, particularly prostate cancer, hepsin is implicated in tumor progression and metastasis by promoting extracellular matrix degradation, thereby facilitating tumor invasion and spread. Aberrant expression or activity of hepsin is associated with pathophysiological changes in the tumor microenvironment, making it a target for therapeutic interventions aimed at controlling cancer progression. Research continues to explore hepsin's biochemical functions and regulatory mechanisms, providing insights into its potential roles in both normal physiology and disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Hepsin
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 506220
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene HPN
Gene Accession No. P05981
Gene Alias hepsin; hepsin (transmembrane protease, serine 1); Hlb320; HPN; Serine protease hepsin; Serine protease hepsin catalytic chain; Serine protease hepsin non-catalytic chain; testicular tissue protein Li 85; TMPRSS1; Transmembrane protease serine 1
Gene Symbols HPN
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human Hepsin Ile163-Leu417.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3249
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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