Heptelidic Acid, MP Biomedicals™

Description

Potent, selective, irreversible GAPDH inhibitor, as well as a DNA polymerase inhibitor. The koningic acid molecule, produced by fungi that consume sweet potatoes, has been shown to curb the excessive glucose consumption in tumors exhibiting the Warburg effect and leaving healthy cells alone.

• Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a key enzyme in carbohydrate metabolism, reversibly catalyzes the conversion of GAP to 1,3-bisphosphoglycerate and NAD+
• A sesquiterpene lactone produced by the fungus T. koningii that was shown to have antibiotic activity against anaerobic bacteria such as Bacteroides
• It acts as an irreversible inhibitor of GAPDH that binds to the cysteine-149 residue at the active site of the enzyme (Ki = 1.6 μM)
• Can selectively induce apoptosis in high-glycolytic cancer cells by inhibiting the generation of ATP in the glycolytic pathway
• Heptelidic acid is also a selective and competitive inhibitor of mammalian DNA polymerases β and λ as well as terminal deoxynucleotidyl transferase in family X of DNA polymerases (Kis range from 5.2-9.5 μM)

Specifications

Chemical Identifiers

• CAS: 57710-57-3
• Molecular Formula: C15H20O5
• Synonym: Koningic Acid

• Quantity: 0.25 mg
• Color: White
• Purity: >95
• Molecular Weight (g/mol): 280.3
• Chemical Name or Material: Heptelidic Acid

Safety and Handling

Recommended Storage

-20°C

WARNING: Reproductive Harm - www.P65Warnings.ca.gov