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Heptelidic Acid, MP Biomedicals™
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Quantity:
0.25 mg
1 mg
Description
- Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a key enzyme in carbohydrate metabolism, reversibly catalyzes the conversion of GAP to 1,3-bisphosphoglycerate and NAD+
- A sesquiterpene lactone produced by the fungus T. koningii that was shown to have antibiotic activity against anaerobic bacteria such as Bacteroides
- It acts as an irreversible inhibitor of GAPDH that binds to the cysteine-149 residue at the active site of the enzyme (Ki = 1.6 μM)
- Can selectively induce apoptosis in high-glycolytic cancer cells by inhibiting the generation of ATP in the glycolytic pathway
- Heptelidic acid is also a selective and competitive inhibitor of mammalian DNA polymerases β and λ as well as terminal deoxynucleotidyl transferase in family X of DNA polymerases (Kis range from 5.2-9.5 μM)

Specifications
Specifications
Quantity | 0.25 mg |
Color | White |
Purity | >95 |
Molecular Weight (g/mol) | 280.3 |
Chemical Name or Material | Heptelidic Acid |
Safety and Handling
Recommended Storage | -20°C |
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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