Invitrogen™ HERC5 Polyclonal Antibody

Catalog No.	Quantity
PIPA542317	100 μL

Catalog No. PIPA542317 Supplier Invitrogen™ Supplier No. PA542317

Description

Rabbit Polyclonal Antibody

Peptide sequence: CLVAELVGYR VTQIACGRWH TLAYVSDLGK VFSFGSGKDG QLGNGGTRDQ Sequence homology: Cow: 86%; Dog: 79%; Human: 100%.

HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.

Specifications

• Antigen: HERC5
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: HERC5
• Gene Accession No.: Q9UII4
• Gene Alias: CEB1; CEBP1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; HERC5; probable E3 ubiquitin-protein ligase HERC5
• Gene Symbols: HERC5
• Host Species: Rabbit
• Immunogen: Synthetic peptide directed towards the N-terminal of human HERC5 (aa 287-336).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51191
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG