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Invitrogen™ HERC5 Polyclonal Antibody
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Catalog No. PIPA560556
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100 μL
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PIPA560556 100 μL
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Catalog No. PIPA560556 Supplier Invitrogen™ Supplier No. PA560556
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SKIKLLHTDT LLKIESKKHK AYLRSAAIEE ERESEFALRP TFDLTVRRNH LIEDVLNQLS QFENEDLRKE LWVSFSGEIG YDLGGVKKEF FYCLFA Highest antigen sequence identity to the following orthologs: Mouse - 44%, Rat - 43%.

HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HERC5
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HERC5
Gene Accession No. Q9UII4
Gene Alias CEB1; CEBP1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; HERC5; probable E3 ubiquitin-protein ligase HERC5
Gene Symbols HERC5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human HERC5. Recombinant protein control fragment (Product #RP-96656).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51191
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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