Invitrogen™ HERV Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579220

Catalog No. PIPA579220

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human K562 whole cell, human SH-SY5Y whole cell, human MCF-7 whole cell.

HERVs are a class of multiple sclerosis associated retroviruses. Reacts with a replication competent Human Endogenous Retrovirus (HERVW) isolated from placenta. The synthetic peptide sequence used as immunogen is taken from the virus envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. The HERVW endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.

Specifications

• Antigen: HERV
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERVW-1
• Gene Alias: endogenous retroviral family W, env(C7), member 1; endogenous retrovirus group W member 1; endogenous retrovirus group W, member 1; ENV; envelope glycoprotein; envelope polyprotein gPr73; envelope protein; Enverin; ENVW; Env-W; ERVW-1; ERVWE1; gp24; gp50; HERV7Q; HERV-7q; HERV-7q envelope protein; HERV-tryptophan envelope protein; HERVW; HERV-W Env glycoprotein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; HERVWENV; HERV-W-ENV; human endogenous retrovirus W envC7-1 envelope protein; SU; Surface protein; Syncytin; syncytin A; syncytin-1; TM; Transmembrane protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 30816
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: Q9UQF0
• Gene Symbols: ERVW-1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ERVW-1 (406-435aa YYVNQSGIVTEKVKEIRDRIQRRAEELRNT).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG