Invitrogen™ HERV Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595785

Catalog No. PIPA595785

Description

Positive Samples: U-251MG, 293T, mouse brain; Cellular Location: Cell membrane, Peripheral membrane protein, Single-pass type I membrane protein, Virion Immunogen sequence: PEQWNNFSTE INTTS.

HERVs are a class of multiple sclerosis associated retroviruses. Reacts with a replication competent Human Endogenous Retrovirus (HERVW) isolated from placenta. The synthetic peptide sequence used as immunogen is taken from the virus envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. The HERVW endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.

Specifications

• Antigen: HERV
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERVW-1
• Gene Alias: endogenous retroviral family W, env(C7), member 1; endogenous retrovirus group W member 1; endogenous retrovirus group W, member 1; ENV; envelope glycoprotein; envelope polyprotein gPr73; envelope protein; Enverin; ENVW; Env-W; ERVW-1; ERVWE1; gp24; gp50; HERV7Q; HERV-7q; HERV-7q envelope protein; HERV-tryptophan envelope protein; HERVW; HERV-W Env glycoprotein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; HERVWENV; HERV-W-ENV; human endogenous retrovirus W envC7-1 envelope protein; SU; Surface protein; Syncytin; syncytin A; syncytin-1; TM; Transmembrane protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 30816
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9UQF0
• Gene Symbols: ERVW-1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 201-300 of human ERVW-1 (NP_0554053).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov