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Invitrogen™ HES4 Polyclonal Antibody
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Catalog No. PIPA541167
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100 μL
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PIPA541167 100 μL
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Catalog No. PIPA541167 Supplier Invitrogen™ Supplier No. PA541167
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Description

Rabbit Polyclonal Antibody

Peptide sequence: MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSKP VMEKRRRARI Sequence homology: Cow: 86%; Dog: 93%; Human: 100%; Pig: 85%; Rat: 77%.

HES4, or Hes Family BHLH Transcription Factor 4, is a gene located on chromosome 1p36.31, encoding a basic helix-loop-helix (bHLH) transcription factor that plays a role in the Notch signaling pathway. This pathway is integral to cell differentiation, proliferation, and apoptotic processes, especially during embryonic development and tissue homeostasis. HES4 acts as a transcriptional repressor, regulating the expression of genes responsible for maintaining stem cell populations and inhibiting premature differentiation. While its exact biological roles are still being elucidated, studies suggest HES4 influences neurogenesis and myogenesis by modulating the timing of differentiation events within progenitor cells. The dysregulation of HES4 can impact normal developmental processes, potentially contributing to pathologies such as cancer and developmental disorders due to its control over cellular growth and differentiation pathways. Research into HES4 continues to advance understanding of its functions within the context of Notch signaling and its implications for disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HES4
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene HES4
Gene Accession No. Q9HCC6
Gene Alias bHLH factor Hes4; bHLHb42; Class B basic helix-loop-helix protein 42; hairy and enhancer of split 4; hes family bHLH transcription factor 4; HES4; hHES4; transcription factor HES-4
Gene Symbols HES4
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human HES4 (aa 1-50).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57801
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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