HES6 Mouse anti-Human, Clone: OTI3H10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF800749

Catalog No. 50-166-5297

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Specifications

• Antigen: HES6
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: HES6
• Gene Alias: C-HAIRY1, HES-6, bHLHb41, bHLHc23
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55502
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3H10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96HZ4
• Gene Symbols: HES6
• Immunogen: Full length human recombit protein of human HES6 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a