Invitrogen™ HES6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536278

Catalog No. PIPA536278

Description

This antibody detects endogenous protein at a molecular weight of 30 kDa. Purity is >95% by SDS-PAGE.

The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Specifications

• Antigen: HES6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HES6
• Gene Alias: AI326893; bHLHb41; bHLHc23; C-HAIRY1; class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; hes family bHLH transcription factor 6; hes6; HES-6; Transcription cofactor HES-6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 316626, 55502, 55927
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96HZ4, Q9JHE6
• Gene Symbols: HES6
• Immunogen: Synthetic peptide corresponding to the N-terminal of human HES-6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov